Use the contents of this vial within three months of initial broaching. Discard the unused portion. Guaiphenesin is administered for casting horses. Premedication with acetylpromazine and/or xylazine (Xylazil 100) smooths and accelerates the onset of recumbency, and xylazine significantly reduces the required dose of guaiphenesin.
Sole use. Guaiphenesin Injection may be administered alone to effect or at a dose rate of 360 to 450 mL/450 kg bodyweight, to provide recumbent restraint of six to eight minutes’ duration. Premedicate with 2.25 mL of acepromazine 10 mg/mL per 450 kg bodyweight.
Combination use. Guaiphenesin Injection may be employed in combination general anaesthetic regimens as follows.
Thiopentone sodium. Premedicate with 2.25 mL of acepromazine 10 mg/mL per 450 kg bodyweight. Add thiopentone sodium 2.5 g in 20 mL volume to the 500 mL guaiphenesin vial, and administer rapidly by IV injection to effect. Alternatively, administer guaiphenesin 360 to 450 mL/450 kg bodyweight followed by a bolus dose of thiopentone sodium 5.5 mg/kg bodyweight.
Thiamylal sodium. Premedicate with 2.25 mL of acepromazine 10 mg/mL per 450 kg bodyweight. Add thiamylal sodium 2 g in 20 mL volume to the 500 mL guaiphenesin vial and administer rapidly by IV to effect.
Xylazine. Administer guaiphenesin 360 to 450 mL/450 kg bodyweight, then administer xylazine 1.1 mg/kg bodyweight by IV injection, followed five minutes later by guaiphenesin 250 to 270 mL/450 kg bodyweight by rapid IV infusion to effect.
Xylazine plus ketamine. Administer xylazine 1.1 mg/kg bodyweight by IV injection, followed five minutes later by an IV infusion of guaiphenesin 250 to 270 mL/450 kg bodyweight to produce recumbency. Immediately following recumbency, administer ketamine 1.7 mg/kg bodyweight by IV injection.
Administration to food producing species of animals, or administration for caesarean section when fetal viability is important, as significant amounts of the drug cross the placental barrier.
