Methadone 20mL

Description

For analgesia and restraint in horses, and analgesia and anaesthetic premedication in dogs and cats.

Product Information

Analgesia and restraint in horses, and analgesia and anaesthetic premedication in dogs and cats. Analgesia peaks between 10 and 20 minutes postadministration and persists for three to five hours.
Horses. Analgesia and restraint. When methadone is used in combination with acetylpromazine injection, it is an effective agent of restraint and analgesia, facilitating treatment of wounds, handling and loading of difficult animals, suturing, laryngoscopy, castration and minor surgical procedures. Following intravenous (IV) administration, the onset of action is rapid and clinical effect is usually sufficient to begin the procedure within three minutes. Horses rarely become recumbent or ataxic after methadone?acetylpromazine administration, even at high doses. Clinical doses produce a somnolent but aware state in which the animal is tractable, placid and sufficiently coordinated to minimise risk of injury to animal or operator. Methadone may be employed as a premedicant to xylazine sedation or barbiturate or ketamine anaesthesia to provide effective analgesia and restraint during painful procedures.
Dogs. Analgesia and premedication. Methadone Injection is used in premedication of barbiturate anaesthesia. Barbiturates have extremely poor analgesic properties, even at high dose rates. Methadone premedication of barbiturate anaesthesia smooths induction and greatly minimises the risk of drug toxicity by enabling the dose of barbiturate to be halved.
Cats. Methadone is used as a premedicant for inhalational anaesthesia. Compatability with acepromazine and propofol has been demonstrated. Repeat doses of methadone for analgesia can be given at three time points with 5 hour intervals.

Dosage and Admin

Horses. Analgesia. Give 0.22 mg/kg (10 mL/450 kg) bodyweight by intramuscular (IM) or subcutaneous (SC) injection. Restraint. Give 0.11 mg/kg (5 mL/450 kg) bodyweight combined with acetylpromazine 0.055 mg/kg bodyweight (acetylpromazine 2.5 mL of 10 mg/mL per 450 kg bodyweight) by IV injection.
Dogs. Analgesia. Give 0.11 to 0.55 mg/kg (0.11 to 0.55 mL/10 kg) bodyweight by IM or SC injection. Premedication. Give 1.1 mg/kg (1.1 mL/10 kg) bodyweight by SC injection.
Cats. Analgesia, premedication, repeat analgesia. 0.2 to 0.6 mg/kg (0.2 to 0.6 mL/10 kg) bodyweight by SC injection. Repeat analgesia 0.2 to 0.6 mg/kg (0.2 to 0.6 mL/10 kg) bodyweight by SC injection at three time points with 5 hour intervals.

CONTRAINDICATIONS

Administration during parturition, or to animals with severe respiratory depression. Administration to pregnant, breeding or lactating cats, as safe use of the product in these animals has not been evaluated. Safe use of this formulation in cats less than 1 year of age has not been established. Published information supports the safe and effective use of methadone in cats older than 6 months.
Precautions Use with caution in animals with hypothyroidism, adrenocortical insufficiency, impaired renal and hepatic function, head trauma and shock.
Disposal Return any unused product to a pharmacy or pharmacy inspector.

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