Flunixil inhibits the wide ranging effects of prostaglandins within the body and therefore has many clinical uses in veterinary medicine.
General. Potent antipyretic; endotoxic/septic shock; antiplatelet therapy; accident cases, e.g. shock, trauma; heatstroke.
Musculoskeletal conditions. Alleviation of pain and inflammation that often causes lameness, discomfort or recumbency, e.g. arthritis, intervertebral disc disease, navicular disease, contusions, abrasions, carpitis, tendinitis, gonitis, footrot, cellulitis, myositis, laminitis, etc; suppression of postoperative swelling and lameness.
Gastrointestinal conditions. Restoration of normal peristalsis by relieving spasm of the smooth muscle, e.g. acute foal/calf/piglet (coliform) diarrhoea, parvovirus infection of dogs; visceral analgesia; reduction of arterial hypoxaemia, lactic acidosis, colic and diarrhoea resulting from the prostaglandin released by damage to the intestinal endothelium; relief of pain associated with equine colic, preventing self-injury and affording the clinician the means to a safe and thorough examination of the animal; reduction of prostacycline induced vasodilation and visceral pooling of blood in serious abdominal crises prior to exploratory laparotomy; inhibition of the effects of endotoxin.
Ocular conditions. Control of painful ocular conditions, e.g. injury, uveitis and keratitis; control of ocular swelling before and after certain surgical procedures such as cataract removal.
Respiratory conditions. Reduction of shock associated pulmonary hypertension.