Ilium Xylazil-100

Injection

Actions
XYLAZIL-100 produces dose dependent sedation and analgesia through an alphamimetic and direct opioid effect. It also produces muscle relaxation by inhibition of the intraneuronal transmission of impulses centrally in the CNS.

Onset of action after intravenous injections is rapid, with effective sedation present within 3-5 minutes and after intramuscular
or subcutaneous administration, it occurs within 10-15 minutes. The sedative effect usually lasts 1 - 2 hours, while the analgesic effect lasts only 30-40 minutes. The analgesic effect in the horse is not as profound as in cattle.

The usual response to XYLAZIL-100 administration in the horse is drooping of the head, ataxia without recumbency, penile prolapse which does not progress to paraphimosis, and pendulous lower lip. Complete recovery varies with the doses administered, however it is usually uneventful and requires minimal supervision.

Indications
An analgesic, sedative and muscle relaxant injection for use in horses.

Directions for use
XYLAZIL-100 is an extremely useful sedative in the horse allowing a number of procedures to be more easily conducted e.g. ophthalmic examination, wound suturing and standing surgery (such as castration) in association with appropriate local anaesthesia, stomach tubing or endoscopic examination of fractious patients, radiography, dentistry, bandage application and removal etc.

XYLAZIL-100 is also a very effective premedicant for both ketamine and barbiturate anaesthesia.

Dose rate: 0.5-1.1mg/kg b.w.
(0.5-1.1mL/100kg bodyweight)
by slow Intravenous injection.

Presentation
Injection 50mL.

Composition
Xylazine as hydrochloride 100mg/mL.

Precautions
Painful stimuli may cause an apparently deeply sedated patient to react inappropriately and, therefore, adequate care should be taken. It is normal for XYLAZIL-100 to cause cardiopulmonary depression manifested by a decrease in heart rate, stroke volume, cardiac output and respiratory rate together with an increase in total peripheral resistance.

The effects are transitory and of no clinical significance in healthy animals, however it is not recommended to use XYLAZIL-100 where there is cardiovascular disease including conditions of shock or respiratory depression.

A number of cardiac dysrhythmias such as second degree atrioventricular block, have been encountered with xylazine administration and it is believed that increased vagal tone is responsible for these. Premedication with atropine sulphate will help prevent their occurrence, although care must be taken as atropine sulphate is known to be associated with colic in the horse.

Contraindications
XYLAZIL-100 should not be administered to animals in the last trimester of pregnancy as it may precipitate an early parturition or abortion due to the oxytocic effect on the uterus. XYLAZIL-100 should not be administered intra-arterially.

Withholding period
Meat – Do not use less than 28 days before slaughter for human consumption.

Storage
Store below 30ºC (room temperature).

Registration
All states

APVMA Number
38654